Clinical Application of Letrozole in Gynecology – Explained by Dr. Sachin Dalal
When it comes to addressing ovulation issues and fertility challenges in women, Letrozole has emerged as a significant game-changer in the field of gynecology. According to Dr. Sachin Dalal, a leading gynecologist and infertility specialist in Bhandup, Mumbai, Letrozole offers safer and more effective outcomes, particularly in cases of anovulation, polycystic ovarian syndrome (PCOS), and infertility treatment.
Understanding Letrozole: Mechanism of Action
Before exploring its gynecological applications, it’s crucial to understand how letrozole works. Dr. Dalal explains, “Letrozole functions by inhibiting the aromatase enzyme, which is responsible for converting androgens (male hormones) into estrogens (female hormones) in the body. By reducing estrogen levels, letrozole plays a crucial role in managing conditions sensitive to estrogen.”
Clinical Applications of Letrozole in Gynecology
1. Ovulation Induction in PCOS Patients
Letrozole is now first-line therapy for women with PCOS. Studies have shown higher ovulation and live birth rates compared to Clomiphene Citrate.
2. Unexplained Infertility
Letrozole is used for ovulation stimulation in women with unexplained infertility undergoing intrauterine insemination (IUI). It ensures controlled follicular development with a lower risk of multiple pregnancies.
3. Endometriosis-related Infertility
Letrozole can reduce estrogen-dependent endometriotic lesions and help in improving fertility outcomes in women with mild to moderate endometriosis.
4. Frozen Embryo Transfer (FET) Cycles
For patients undergoing FET in IVF, Letrozole can be used for endometrial preparation with minimal hormonal disturbance.
5. Breast Cancer Patients Desiring Pregnancy
Letrozole is considered safe and effective for ovulation induction in breast cancer survivors, as it does not significantly raise estrogen levels.
Advantages of Letrozole Over Clomiphene Citrate
According to Dr. Sachin Dalal:
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Higher live birth rate
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Lower risk of multiple gestations
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Better endometrial receptivity
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Minimal anti-estrogenic effect on cervical mucus
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Final Thoughts by Dr. Sachin Dalal
“Letrozole has revolutionized the way we manage infertility, especially in women with PCOS. It’s effective, safe, and well-tolerated. However, the success of treatment depends on individualized evaluation and careful monitoring,” says Dr. Dalal.